Application of super-resolution imaging methods for cell biology and translation medicine
Dr. Vito Mennella
NIHR Biomedical Research Center, University of Southampton
Prof. Vito Mennella has pioneered the application of multimodal super-resolution imaging in cell biology, in particular to study organelle architecture (Trends in Cell Biology, 2014, 2015).
By leveraging the power of 3D-SIM, dSTORM microscopy and quantitative image analysis, he has made together with his team a series of paradigm-shifting discoveries in centrosome and cilia biology: 1. The organized molecular architecture of the pericentriolar material of centrosomes (Nature Cell Biology, 2012); The architecture and function of a novel centrosomal complex in situ (Elife, 2018) and characterization of a novel type of cilium in the airway (Developmental Cell, 2020, 2020 in press).
Most recently he collaborated with clinicians to build super-resolution based tools for translational research in diseases caused by motile cilia defects and apply machine learning methods for disease diagnosis (Science Translational Medicine, 2020). In his presentation he will give an overview of how different super-resolution modalities and quantitative image analysis were applied to drive discovery in these different areas of research.
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